Smoking has been shown to inhibit calcium absorption. They are good drugs and are relatively safe, but for most people there is a lifestyle alternative. Bone ; Medscape App Get fast, accurate answers for point-of-care decision making. Conclusion and policy implication In summary, regular use of PPI was associated with increased risk of hip fracture among postmenopausal women, with the strongest risk observed in individuals with the longest duration of use or with a history of smoking.
Moreover, in separate analyses, there were no independent associations between reported heartburn, acid reflux, or peptic ulcer disease and risk of hip fracture data not shown.
Consistent with prior studies, 3 10 we did observe a significant, though more modest, association with hip fracture among women who used H 2 blockers, which are less potent acid suppressors than PPI. Smoking, smoking cessation, and risk of hip fracture in women. To find the most current information, please enter your topic of interest into our search box. Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.
If you or your child has experienced severe Protonix side effects, contact an RxRecall. Pharmacoepidemiol Drug Saf ; Nevertheless, our finding that the risk of fracture was confined to women with a history of smoking, an established risk factor for fracture, 19 may provide additional mechanistic insight.
After some years of pain and confusion of what is going on?
Do proton pump inhibitors decrease calcium absorption? However, heterogeneity in risk associated with PPI type or dose would tend to bias our results toward the null.
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We also conducted a meta-analysis of our data with the results of published studies assessing the relation between chronic PPI use and risk of hip fracture.
Zantac, cimetidine, Pepcid, Axid, etc.
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Hip Pain While Using Protonix®
Conclusion Chronic use of PPIs is associated with increased risk of hip fracture, particularly among women with a history of smoking. Abstract Objective To examine the association between chronic use of proton pump inhibitors PPIs and risk of hip fracture.
Women who first reported PPI use in had a fully adjusted hazard ratio of hip fracture of 1. Acid-suppressive medications and risk of bone loss and fracture in older adults.