If minor adverse effects develop as the dosage is increased, reduce the dosage rapidly to a tolerated dose and observe the patient closely. Tell your doctor if you are pregnant or if you plan to become pregnant.
The pharmacological activity of indomethacin extended-release in reducing inflammation, and possibly fever, may diminish the utility of diagnostic signs in detecting infections. Indomethacin is a drug belonging to the group of anti-inflammatory drugs NSAIDswhich reduce pain and inflammation.
Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, patients with volume depletion, and the elderly. Use of indomethacin may blunt the CV effects of several therapeutic agents used to treat these medical conditions e. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur e. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.
There have been cases of hepatotoxicity reported in pediatric patients with juvenile rheumatoid arthritis, including fatalities.
What conditions does Indomethacin Capsule, Extended Release treat?
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Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment.
A ] Given the nature of the pharmaceutical market, some specialties may be unavailable, have been removed from the pharmaceutical market or have changed its name.
However, get medical help right away if you notice any symptoms of a serious allergic reactionincluding: Discuss the risks and benefits of treatment with your doctor.
Co-morbid conditions, such as coagulation disorders, or concomitant use of warfarin, other anticoagulants, antiplatelet agents e. If you develop nasal bleedingsore throatsoreness or infections talk to your doctor. Indomethacin affords relief of symptoms; it does not alter the progressive course of the underlying disease.
In published studies in pregnant mice, indomethacin produced maternal toxicity and death, increased fetal resorptions, and fetal malformations at 0. Use of antacids may be helpful. In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. This medicine may make you feel drowsy, tired, dizzy, or may affect the vision.
Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function see WARNINGS: Indomethacin extended-release may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis.
Does Indomethacin Capsule, Extended Release interact with other medications?