Serum phenytoin concentration

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In Tietz Textbook of Clinical Chemistry. The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication.

How should I store Dilantin?

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Phenytoin pharmacokinetics are significantly affected by a number of other drugs. Unless you enable Javascriptyour ability to navigate and access the features of this website will be limited.

However, patients should be cautioned not to miss a dose, inadvertently. Measure ethanol level for multiple ingestions or altered mental status.

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Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes [see Drug Interactions 7. If early signs of dose-related central nervous system CNS toxicity develop, serum levels should be checked immediately. Some people will experience seizures at the low end of the therapeutic range and some people will experience excessive side effects at the upper end.

In the blood, phenytoin is highly bound to serum proteins. Drugs whose level is decreased by phenytoin. The outcome of phenytoin toxicity is not as serious as phenobarbital because phenytoin is not a central nervous system sedative. Phenytoin Synonyms Epanutin Clinical Indications Phenytoin is a primary anticonvulsant for prophylaxis and treatment of partial and generalised tonic-clonic seizures.

Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin.

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The Test How is it used? Administration of phenytoin and interpretation of serum phenytoin levels vary depending on the clinical scenario. Concomitant use of valproic acid alters free phenytoin levels by competitively binding to serum albumin. General information about the safe and effective use of Dilantin.

Laboratory Studies

Differences between the measured and calculated free serum phenytoin concentrations in epileptic patients. Toxic symptoms can affect the mouth, cardiovascular and nervous systems, and the eyes and include:. Anaphylaxis has also been reported.

Dilantin mg extended capsules are available as hard, filled No.

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Other patients are adequately controlled at lower concentrations and there is no need to use higher doses in such patients. Print this section Print the entire contents of. This Medication Guide has been approved by the U.

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