Vancomycin-induced neutropenia in a patient positive for an antineutrophil antibody. Other drugs may cause nonimmunologic protein adsorption onto drug-treated red cells. She died 24 hours after her last dose of IVIG of congestive heart failure. Thomas Monson, W. Computer-aided diagnosis software for vulvovaginal candidiasis detection from Pap smear images.
With oral contraceptives, risk of arterial and venous thrombosis may increase with age, genetic thrombophilias, smoking, and use of certain types of associated progestin [ 53 ]. The deficiency is X-linked, so manifested more commonly and severely in males.
Acetylation of cyclooxygenase 1 COX 1 leads to impaired synthesis of the important platelet agonist thromboxane. Purchase access Subscribe now. The patient was transferred to the intensive care unit after becoming hypotensive, and treatment was changed to vancomycin and imipenem figure 1.
Young NSed. Myelodysplasias and secondary acute leukemias induced by chemotherapy, discussed below, may initially manifest as sideroblastic anemia [ 22 ].
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Email alerts New issue alert. To capture data from patients who had low baseline values, we evaluated the lowest count during therapy and the percentage change from baseline. Acute thrombocytopenic purpura in relation to the use of drugs. Citing articles via Web of Science Rituximab, an anti-CD20 antibody, used in the treatment of B cell lymphoproliferative disorders and in benign autoimmune disorders, can induce neutropenia, typically of delayed-onset [ 77 ].
Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications. Thrombotic microangiopathies TMAs present with thrombocytopenia, microangiopathic hemolytic anemia, and symptoms of microvascular occlusion. Quinine may also induce TMA. Cessation of linezolid therapy resulted in a rapid increase in RBC production and resolution of anemia.
Methemoglobinemia, characterized by excess production of methemoglobin, causes impairment in the transport of oxygen. However, celecoxib, rofecoxib, and valdecoxib were found to be associated with increased thrombotic cardiovascular events in several trials [ 48 — 50 ].
Acalculous cholecystitis in a female with cardiac device-related infective endocarditis. Effects of linezolid on hospital length of stay compared with vancomycin in treatment of methicillin-resistant Staphylococcus infections: