Oral bioavailability is 77 percent, and the drug is quickly converted to its active form. Topical penciclovir Denavir for the treatment of recurrent herpes labialis reduces time to healing and duration of pain by about half a day Boon et al. Genital herpes when and how to treat. Like acyclovir, valacyclovir rarely causes side effects.
The mean elimination half-life is 2. Study three compared standard-dose valacyclovir against high-dose valacyclovir 1, mg three times daily.
Usual Adult Dose for Herpes Simplex - Mucocutaneous/Immunocompetent Host
Suppression of recurrent oral herpes infections has been accomplished with single daily doses of mg. Fever, nausea, vomiting, abnormal serum hepatic enzymes, anemia, granulocytopenia, and genital ulcerations also have been reported.
Many infants are exposed to acyclovir each year, and no adverse effects in the fetus or newborn attributable to the use of this drug during pregnancy have been reported.
Animal studies show risk and human studies not available or neither animal nor human studies done.
Dosing & Uses
HSV exists as two separate types, labeled 1 and 2, which have affinities for different body sites. Daily administration of acyclovir maintains a high degree of efficacy and little toxicity, even after more than 5 years of continuous suppressive therapy Goldberg et al. Long-term suppressive therapy reduces the number of recurrences of oral infection in those with histories of frequent recurrences Rooney et al.
Apply 50 mg 1 buccal tablet as a single-dose to the upper gum region canine fossa Comments: June 4, Page last updated: Valaciclovir is indicated for the treatment of herpes zoster, and for the treatment or suppression of genital herpes.
In addition, administration of acyclovir might be considered for neonates born to women who acquired HSV near term because the risk for neonatal herpes is high for these infants. Time until all lesions are crusted. In the high-dose acyclovir study, no SEM patients developed neurologic sequelae at 12 months of life Kimberlin et al. Earn up to 6 CME credits per issue. Treatment of recurrent herpes simplex labialis with oral acyclovir.
Two types of HSV can cause genital herpes: Resistance occurs as a result of DNA polymerase mutations Kimberlin et al. Acyclovir is in many regards the prototypic antiviral agent.