See "Pharmacotherapy for schizophrenia: Schizophr Res ; SchatzbergCharles DeBattista Limited preview - The potent anti-alpha-adrenergic effects of clozapine, which relax the bladder-neck sphincter, are hypothesized to contribute to the incontinence. If neutropenia develops during treatment, clozapine would either need to be monitored more frequently, stopped temporarily, or discontinued, based on the severity of neutropenia [ 1 ]:.
The major metabolite of clozapinenorclozapine desmethyl-clozapinehas failed to demonstrate any therapeutic activity in clinical trials. Can J Psychiatry ; For at least the initial four weeks of clozapine treatment, all patients should be monitored for early signs of myocarditis. For further information, see www.
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See 'Benign ethnic neutropenia' below. Collaboration with hematology is recommended to manage moderate or severe neutropenia in this patient group. Monitoring should include assessment of clinical status for subjective signs of distress, vital signs at each visit, and weekly laboratory tests, eosinophil count, sedimentation rate or C-reactive protein, and troponins.
JAZZ today announced U. Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? Animal studies have failed to demonstrate a risk to fetus; no adequate human studies. See "Approach to the adult with unexplained neutropenia", section on 'Benign ethnic neutropenia'.
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Clozapine, diabetes mellitus, hyperlipidemia, and cardiovascular risks and mortality: Reducing clozapine-related morbidity and mortality: Initiate treatment at In a review of patients treated with clozapine, the cumulative seizure risk was estimated to be 10 percent after 3. J Emerg Med ; Jazz Pharmaceuticals also has a number of products marketed outside the U. Statins decrease the occurrence of venous thromboembolism in patients with cancer.
J Clin Psychiatry ; 55 Suppl B: Patients with an elevated seizure risk, including those with an alcohol use disorder or a history of febrile seizures or epilepsy, should be considered for prophylactic treatment with an anticonvulsant drug when clozapine is initiated.
This will aid patients in getting to sleep and avoiding daytime sedation. In patients with suspected myocarditis or cardiomyopathy, echocardiography is a key imaging test to assess ventricular function and valve function.