Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Steroid administration was excluded from these clinical trials. Marketing authorisation number s 9. Stratified, randomized, double-blind comparison of intravenous ondansetron administered as a multiple-dose regimen versus two single-dose regimens in the prevention of cisplatin-induced nausea and vomiting.
Choose courses based on your needs. The released serotonin may stimulate the vagal afferents through the 5-HT 3 receptors and initiate the vomiting reflex.
Asymptomatic increases in liver function tests 3. The differences in pharmacokinetic parameters in the 1 to 4 month patient population can be explained in part by the higher percentage of total body water in neonates and infants and a higher volume of distribution for water soluble drugs like ondansetron. Develop Your Own Curriculum. Consequently in such patients repeat dosing will give drug exposure levels no different from those of the general population.
Each 4-mg and 8-mg orally disintegrating tablet contains less than 0. Ondansetron has no effect on plasma-prolactin concentrations. Prevention of postoperative nausea and vomiting.
The mechanisms of action in post-operative nausea and vomiting are not known but there may be common pathways with cytotoxic induced nausea and vomiting. Adults and children age 4 and older: While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Clinical pharmacology of ondansetron in postoperative nausea and vomiting.
Because of the multiplicity of metabolic enzymes capable of metabolizing ondansetron, it is likely that inhibition or loss of one enzyme e. In healthy subjects, single intravenous doses of 0. Circulating drug also distributes into erythrocytes. Comprar livros no Google Play Procure a maior eBookstore do mundo e comece a ler hoje na web, no tablet, no telefone ou eReader.
Circadian variations in the pharmacokinetics of ondansetron [abstract].
Zofran ODT Dosage and Administration
The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment. Based on reports of profound hypotension and loss of consciousness when ondansetron was administered with apomorphine hydrochloride, concomitant use with apomorphine is contraindicated. Ondansetron is absorbed from the gastrointestinal tract and undergoes some first-pass metabolism.