Mitotic inhibitors are used in cancer treatment, because cancer cells are able to grow and eventually spread through the body metastasize through continuous mitotic division. Microtubules are long polymers made of smaller units monomers of the protein tubulin. Microtubules are created during normal cell functions by assembling polymerizing tubulin components, and are disassembled when they are no longer needed.
Griseofulvinderived from a species of Penicillium is an mitotic inhibitor that is used as an antifungal drug. The cells respond to both agents by complete suppression or by abnormal development of the spindle.
Differences in response to colchicine by differentiating xylem cells in roots of Pisum.
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The response of root meristems to colchicine and indol-3yl-acetic acid in Vicia faba L. The response to colchicine of meristems of roots of Vicia faba.
Formative and proliferative cell divisions, cell differentiation, and developmental changes in the meristem of Azolla roots. Probenecid Sulfinpyrazone Benzbromarone Isobromindione. Their principal mechanism is the disruption of the cell's microtubule function by stabilizing microtubule formation. Published 14 May Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxeldocetaxelvinblastinevincristineand vinorelbine. Spermatogonia and spermatocytes, unlike the epidermal cells, invariably show complete spindle suppression during cold treatment.
Taiwania 17— The basis of c-tumor formation in Phleum pratense. Protoplasma 72— Unable to display preview.
A supplementary study on the cell division of root apical cells in some Pteridophytes. Caryologia 2153— The inactivation effects can be described in terms of a tactoid theory, as due to surface changes in centrosomes or centromeres which prevent them orientating or breaking down spindle molecules.
The effects of colchicine on the ultrastructure of dividing plant cells, xylem wall differentiation and distribution of cytoplasmic microtubules. Vinca alkaloids inhibit microtubule polymerization. Search for this keyword.
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Podophyllotoxin derived from the may apple plant, is used to treat viral skin infections and synthetic analogues of the molecule are used to treat certain types of cancer.
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